AG Waring, of Coombe Meadows, Chillington, writes: We would be wise to ignore the hype engendered by government proposals to legalise three-parent IVF treatment, so-called mitochondrial transfer. Much is made of this new technology and those in favour use sick children as a moral argument to portray doubters as heartless and uncaring. Mitochondrial transfer would result in a baby whose genetic make-up includes contributions from three individuals. In theory it will prevent the passing on of certain mitochondrial diseases. The procedure is ethically objectionable on the grounds that it involves extensive manipulation of early human life. It causes irreversible changes to the human germline. We have no idea what this means for the future health of the child, or indeed future generations. In many countries it is illegal and international declarations and treaties condemn germline modification strongly. The techniques are not cures as such and will not benefit those already suffering. The measures are intended not to cure, but to eliminate carriers. Unesco and the Nuffield Council on Bioethics have expressed caution. We simply do not know if mitochondrial transfer works. The research calls for an increase in women donating eggs, as a result of which ovarian hyper-stimulation syndrome can result, a painful and debilitating disorder. In summary, there are ethical and public safety concerns and the Government is taking a great risk in endorsing this legislation before the public has had a chance to assess the risks. If you have doubts do not delay in contacting your MP to express your concern.